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Blastocyst Culture

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Blastocyst Culture

What is blastocyst culture?
This term describes the process when the embryos grow for longer in the laboratory, and undergo critical developmental changes before being returned to the womb.This period of extended culture helps our blastocystexperts select the most competent embryo(s) for transfer to your womb, and can help to indicate which embryos have the best growth potential. Therefore, blastocyst culture maximises the chance of you achieving a viable pregnancy.By the time an embryo has reached the blastocyst stage, it’s already undergone several cell divisions and achieved its first cell differentiation into two distinct cell types. Although this period of extended culture doesn’t necessarily improve the quality of the embryos, or guarantee that they reach the blastocyst stage, we have impressive success rates for this treatment.

Who needs blastocyst culture?
You’re likely to benefit from this treatment if you have a large number of embryos. That’s because not all embryos have the ability to form a blastocyst, and the number of embryos progressing each day may decrease. Blastocyst culture allows the most advanced/competent embryo(s) to be selected for transfer on the fifth day following egg collection. Our results indicate that with five or more embryos on day one after egg collection, there’s an improved pregnancy rate using extended culture compared to using day two or three transfers.

Advantages of blastocyst transfer for IVF
» One problem with this is that 2 to 3-day-old embryos are normally n the fallopian tubes, not in the uterus. The embryo gets to the uterus about 80 hours after ovulation.
» Embryo implantation process begins about 3 days later - after blastocyst formation and hatching out of the embryonic shell have occurred.
» If in vitro culture conditions are maximized so healthy blastocysts form at a high rate, then day 5 blastocyst embryo transfer can be done.
» The uterine lining on day 5 should be receptive to the arriving embryo - this a more "natural" time for the embryos to be in the uterus. It is the same timing as with a natural pregnancy.
» The transfer is done shortly before the time for actual invasion and implantation

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